A Comparasion Essay

A minimum of 40 different patient specimens should be tested by the two methods [1].These specimens should be selected to cover the entire working range of the method and should represent the spectrum of diseases expected in routine application of the method.One or two such mistakes could have a major impact on the conclusions drawn from the experiment.

Twenty specimens that are carefully selected on the basis of their observed concentrations will likely provide better information than the a hundred specimens that are randomly received by the laboratory.The term “comparative method” is a more general term and does not imply that the correctness of the method has been documented.Most routine laboratory methods fall into this latter category.Since the long-term replication study will likely extend for 20 days, the comparison study could cover a similar period of time and would require only 2 to 5 patient specimens per day.Specimens should generally be analyzed within two hours of each other by the test and comparative methods [1], unless the specimens are known to have shorter stability, e.g., ammonia, lactate.Stability may be improved for some tests by adding preservatives, separating the serum or plasma from the cells, refrigeration, or freezing.Specimen handling needs to be carefully defined and systematized prior to beginning the comparison of methods study.Several different analytical runs on different days should be included to minimize any systematic errors that might occur in a single run.A minimum of 5 days is recommended [1], but it may be preferable to extend the experiment for a longer period of time.However, information about the constant or proportional nature of the systematic error is also useful and often available from appropriate statistical calculations.Both the experimental design and the statistical calculations are critical for obtaining reliable estimates of systematic errors.


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