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Use them only in the hood and be sure the hood fan is on! Excess chemicals must be disposed of in the plastic tub of water.This will convert the acetic anhydride to vinegar and dilute the sulfuric acid.Using a clean stirring rod, place a crystal of salicylic acid into the first test tube. To each test tube add 1 drop of iron(III) chloride) solution.
If the crystals do not all dissolve, add 2 m L more of the ethanol and continue to warm the mixture to dissolve the crystals. When the crystals are all dissolved, add 10 m L of deionized water, cover the beaker with a watch glass, and allow the solution to cool slowly on the lab bench undisturbed for about 10 minutes. After the 10 minutes cooling on the lab bench, complete the crystallization by placing the beaker and contents in the ice bath. If crystals do not appear, you can scratch the bottom of the beaker with a stirring rod to induce crystallization. Using a clean circle of filter paper, collect the purified aspirin by suction filtration as before. Dry the crystals by pulling air through them for about 15 minutes.
(Discard the filtrate left in the filter flask into the waste container under the hood.
If you spill a lot of either of these, notify your instructor.). Using the graduated cylinder located under the hood, measure out 7.00 m L of acetic anhydride and add this to the flask.
Transfer this to a 125 m L Erlenmeyer flask using a powder funnel. Be sure to do this in the hood and wearing your goggles.
) and allow the flask and contents to cool on the lab bench for about 3 minutes. After the flask has cooled for about 3 minutes, CAUTIOUSLY add 15 m L of room temperature water to the flask to facilitate the decomposition of the excess acetic anhydride. Be sure to seat the filter paper in the filter with a small amount of water. Rinse the flask twice with 3 m L of ice cold water to remove any residual crystals. Discard the filtrate left in the filter flask into the waste container under the hood. Transfer as much of the solid as possible from the Buchner funnel to a clean, dry 250 m L beaker. Add 10 m L of 95% ethanol to the beaker and if necessary, warm (do not boil!
) the mixture in the water bath to dissolve the crystals. If an "oil" appears instead of a solid, reheat the beaker in the hot water bath until the oil disappears.
However, salicylic acid is bitter and irritates the stomach.
A German chemist named Felix Hoffman is credited with being the first to synthesize aspirin in 1897.
Apparently this comes from acetylation (A-), together with Spirin, part of the name for Meadow-sweet (Spiraea ulmaria), a plant rich in salicylates.
Friedrich Bayer, the employer of Hoffman, patented the name and began marketing the product in 1899. Bayer's company set up by himself, is generally reckoned to have been the first pharmaceutical company, and the production of aspirin is generally accepted to have laid the foundation of the modern pharmaceutical industry.